Hello


I'm angela. 


I'm sorry I'm late.


Here's my abstract.


Thank you very much



Vertical bone growth using nanotube surface of titanium implant  


○ 윤귀덕* 


1전남대학교 치의학전문대학원 보철과 

전화(062)530-5631, FAX(062)530-5638, e-mail:ykd@jnu.ac.kr 


The aim of this study is to evaluate the effect of the rhBMP-2 (recombinant human Bone Morphogenetic Protein-2) coated micro-nanotubular surface implants on the supra-alveolar bone formation in beagle dogs.

RBM (Resorbable blast media surface) implants were used in the control group and 40 μg of the recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) solution (1.5 mg/mL) was loaded onto implants with micro-nanotubular surface fabricated using anodic oxidation on RBM implants in the experimental group. A total of 16 implants were placed into the reduced mandibular bone in beagle dogs. Micro-computed tomographic analysis and histomorphometric anlaysis was performed. 

Micro-computed tomographic analysis showed that there was a significant difference between the experimental group and the control group only in induced bone volume at the region of the interest 0.5 mm away from the implant thread. There were significant differences between the experimental group and the control group at 0.5 mm and 1.0 mm away from the implant thread in induced bone height. Implants coated with rhBMP-2 exhibited increased bone formation compared with the control group in regard to the bone height and bone volume. No significant difference was observed in bone mineral density.

The results from the histomorphometric analysis suggest that rhBMP-2 coated implants with micro-nanotubular surface can induce increased bone formation in regard to the bone height, volume and bone to implant contact. The inducing effect could reach 1.0 mm away from the implant thread in regard to the bone volume and 0.5 mm away from the implant thread in regard to the bone height. The rhBMP-2 coated micro-nanotubular implants showed increased bone to implant contact not only within the newly formed bone but also existing bone area.

It is suggested that rhBMP-2 coated micro-nanotubular surface implants are effective on the supra-alveolar bone formation.


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